Patient Education

Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.

procainamide (injection)

Pronunciation: proe KANE a mide

What is the most important information I should know about procainamide injection?

Procainamide can cause serious side effects and is for use only to treat life-threatening heart rhythm problems. If you receive procainamide during an emergency, make sure any follow-up doctor knows you received this medicine.

What is procainamide injection?

Procainamide is used to help keep the heart beating normally in people with certain heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart).

Procainamide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving procainamide injection?

You may not be able to receive procainamide if:

  • you have a serious heart condition such as "AV block" (unless you have a pacemaker);
  • you have lupus;
  • you've had a heart attack;
  • you have long QT syndrome and have had a condition called torsade de pointes; or
  • you've had a severe allergic reaction to a numbing medicine.

If possible during an emergency, tell your medical caregivers if you've ever had:

  • blood circulation problems;
  • a heart attack or stroke;
  • a weak immune system;
  • kidney disease;
  • myasthenia gravis;
  • asthma or sulfite allergy; or
  • an allergy to aspirin.

It is not known if procainamide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed.

How is procainamide injection given?

Procainamide is injected into a muscle or vein by a healthcare provider.

Your heart function, blood pressure, and other vital signs will be watched closely.

You may get infections more easily, even serious or fatal infections. You may need medical tests for a short time after you receive procainamide injection.

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving procainamide injection?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What are the possible side effects of procainamide injection?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your medical caregivers right away if you have:

  • sudden fever, chills, sore throat, mouth sores, weakness;
  • joint pain, muscle pain or weakness;
  • wheezing, chest pain;
  • easy bruising, pale or yellowed skin, dark colored urine;
  • depression, dizziness, hallucinations;
  • stomach pain, nausea, vomiting, diarrhea, loss of appetite; or
  • lupus-like symptoms --joint pain or swelling, stomach pain, chest pain, shortness of breath, and a rash or patchy skin color that worsens in sunlight.

Common side effects may include:

  • stomach pain, loss of appetite, nausea, vomiting, diarrhea;
  • dizziness, weakness, depressed mood;
  • abnormal liver function tests; or
  • rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect procainamide injection?

Tell your doctor about all other medicines you use, especially:

  • digoxin (digitalis) or other heart rhythm medications;
  • bronchodilator asthma medication;
  • cold or allergy medicine (Benadryl and others);
  • medicine to treat overactive bladder;
  • medicine to treat Parkinson's disease; or
  • medicine to treat stomach problems, motion sickness, or irritable bowel syndrome.

This list is not complete. Other drugs may affect procainamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I find more information?

Your doctor or pharmacist can provide more information about procainamide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2022 Cerner Multum, Inc. Version: 6.01. Revision date: 9/13/2021.

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